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No explanation was furnished for that reduction in human body body weight in male mice from the minimal dose team but not the significant dose group through Serious exposure (NTP 1989). Overall body bodyweight reduction isn't going to offer precise details regarding toxicity, and infrequently happens only at doses higher than These causing other systemic results. The relative sensitivity to body-fat reduction does show up to parallel the sensitivity to kidney and liver harm: male rats are most sensitive, accompanied by woman rats, male mice, and female mice (NTP 1989).
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These compounds ended up also cytotoxic against human typical endothelial cells, so these compounds didn't demonstrate any selectivity between the cancer and typical cells.
values, confirming the higher water solubility of derivatives in comparison to guide compound IX, and by far the most pronounced transpired Major carboxamides 2a and 2b.
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benefit in comparison Along with the lead compounds. The exception are three derivatives 1c, 1d, 1e, where the substitution of bromine while in the furan ring (compounds 1d and 1e) or during the methyl group triggered the clog
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